British Rainfall, 1905

Lumbago 1Read before the Bath and Bristol Branch of the British Medical Association, April 26th, 1905.

or quick movement of the muscles affected, at other times first noticed in moving from a position of rest. There is no warning of the first attack, but recurrences may be preceded for a day or two by some stiffness and slight aching of the parts. The pain is felt on any attempted active movement of the lower half of the trunk, especially on rotation or extension; it seems to spread from the spi...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

Mark's Annual Reports, 1905